The Florida Keys are one of the top getaways in the U.S. and one of the best destinations to visit in March because the weather is warm and sunny, and it’s a great starting point to explore more of the Caribbean. So I’ve rounded up the best Florida Keys luxury vacation rentals.

Top Getaways in the Southeast

These vacation homes are the perfect island paradises for exploring The Keys. Plus, you’ll have more space and amenities than a hotel can give you – pools, yards, office spaces, game rooms, and outdoor living.

Here are the best Florida Keys Luxury Vacation Rentals for your trip!

Key West

2 guests · 1 bedroom · 1 bed · 1 bath

This small cottage packs a big punch with its bamboo accents, coastal colors and decor, Cuban tile floors, and the private courtyard and deck. You’ll have access to the complex’s pool and garden, and this home is just a short walk to the beach, Historic Seaport, and Duval Street.

Luxury Houseboat

Key West

6 guests · 2 bedrooms · 3 beds · 2.5 baths

On this spacious houseboat, you’ll have 950 square feet of outdoor living space, including a massive third level sun deck. This property is part of a yacht club, so you’ll have access to all of the club’s amenities – a pool, private beach, gym, restaurant, and oceanside tiki bar.

Paradise

Lower Matecumbe Key

8 guests · 3 bedrooms · 5 beds · 3 baths

This is beachfront living! You’ll love the incredible ocean views, the sandy backyard that leads directly to the ocean, the private boat dock, the four beach cruisers, the hammock, the beach chairs and umbrellas, and the screened-in and furnished back patio.

Real World MTV House

Key West

16 guests · 10 bedrooms · 12 beds · 5.5 baths

If you want to live one of your reality TV fantasies, you can stay in this house, which was featured in The Real World season 17 in 2006. This over-the-top house has a gym, pool table, racket ball court, boat dock, kayaks, paddleboards, bikes, and an amazing pool and patio. So get your crew together to party here!

Big Blu

Key West

12 guests · 5 bedrooms · 5 beds · 4 baths

Here, you’ll be ideally situated just a few blocks from the sea, restaurants, and shops. The floor-to-ceiling windows make the house bright, open, and airy, and the kitchen is a chef’s dream. The saltwater pool is heated with jacuzzi jets, and the patio will make you feel like you’re at a luxury resort.

Heavenly Zen

Key West

8 guests · 4 bedrooms · 4 beds · 3 baths

You’ll never want to leave this island paradise. The inside has vaulted ceilings, open-concept living, coastal decor, and massive doors and windows that make the inside and outside flow together. This home’s courtyard is incredible with a pool, waterfall, covered, lush tropical landscaping, hot tub, and outdoor shower.

Cudjoe Key

4 guests · 2 bedrooms · 2 beds · 2 baths

Enjoy breathtaking ocean views from this beautiful stilt home. You’ll have a full-length concrete seawall, a dock for two boats, heavy-duty dock posts, boat cleats, a swim ladder, a fish cleaning table, and a water hose. You’ll also have an elevator and access to complimentary beach cruiser bikes.

Calle Ensueno

Marathon

10 guests · 4 bedrooms · 4 beds · 3 baths

This tropical oasis is located on Crystal Lagoon and comes with a dock and boat slip. You won’t want to leave the fabulous pool, patio, and wrap around porch, and the kitchen is a chef’s dream come true.

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This article about the best Florida Keys luxury vacation rentals is not a sponsored post, and the thoughts and opinions expressed in this post are entirely my own. Some of the links in this post about the best Florida Keys luxury vacation rentals are affiliate links, and, at no cost to you, I may earn a small commission.