St. Louis is one of the top destinations to visit in the Midwest United States. This beautiful city sits on the Mississippi River, framed by the famous Gateway Arch. So I’ve rounded up the top vacation rental homes in St. Louis, Missouri.

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From boutique lofts to spacious townhomes to baseball-themed houses, these vacation homes will let you explore St. Louis like a local.

Here are the best vacation rental homes in St. Louis, Missouri!

Modern Apartment

4 guests · 2 bedrooms · 2 beds · 1 bath

You’ll have sweeping views of the city from every window in this light, bright, and airy apartment. This loft has comfort and style with plush beds, mid-century-inspired furniture, an open floor plan main space, painted brick masonry walls, and colorful artwork.

Historic Home

6 guests · 3 bedrooms · 3 beds · 3 baths

This early 1900s home is the perfect blend of modern amenities and historic charm. You’ll be on a quiet, beautiful street just a short walk from restaurants, cafes, art galleries, bookstores, parks, and bars.

5 guests · 2 bedrooms · 3 beds · 2 baths

This large apartment is just a few blocks from the Gateway Arch. The brick, exposed ductwork, and arched windows make this a funky urban oasis you’ll never want to leave, especially once you see how tall the ceilings are.

Cozy and Colorful

5 guests · 2 bedrooms · 3 beds · 1 bath

This spacious first-floor apartment is perfect for families or a girlfriends’ getaway. You’ll be centrally located in the Clifton Hieghts neighborhood, and you’ll fall in love with the home’s colorful and funky decor.

Charming Bungalow

4 guests · 2 bedrooms · 2 beds · 1 bath

Embrace your artistic side at this chic, eclectic, and artistic “gingerbread” home. The house is in a quiet neighborhood close to attractions, restaurants, and shopping. You’ll love the bright kitchen, breakfast nook, and yoga room.

THE DUGOUT

16 guests · 4 bedrooms · 18 beds · 2 baths

If you want a unique vacation home, then this 2,400 sq ft baseball-themed property is for you. It’s perfect for reunions, friends groups, and large family gatherings. Plus, you’ll only be an 11-minute walk from Busch Stadium!

Picture-Perfect

8 guests · 3 bedrooms · 3 beds · 2.5 baths

This renovated home has 100-year-old brickwork, cozy furniture, beautiful decor, and complimentary bikes. You’ll be in a quiet, non-tourist neighborhood with easy access to many of St. Louis’s top attractions.

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This article about the best vacation rental homes in St. Louis, Missouri is not a sponsored post, and the thoughts and opinions expressed in this post are entirely my own. Some of the links in this post about the best vacation rental homes in St. Louis, Missouri are affiliate links, and, at no cost to you, I may earn a small commission.