San Diego is the perfect destination for a girls’ trip, mother-daughter getaway, romantic escape, or a solo trip. The city is known for its beaches, parks, warm climate, and outdoor activities. So I’ve rounded up the top San Diego luxury vacation home rentals.

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Whether you’re on a Southern California road trip or need a staycation, these vacation homes are the perfect way to explore San Diego like a local.

Here are the best San Diego luxury vacation home rentals!

Bayfront Cottage

4 guests · 2 bedrooms · 3 beds · 1 bath

Get ready to fall in love with this picture-perfect ground-floor condo on Mission Beach. You’ll never want to leave the patio, the inside is newly remodeled, and this home has an on-site parking spot. You’ll be just a short walk from Belmont Park, the ocean, restaurants, shops, bars, and other attractions.

Peaceful Casita

2 guests · Studio · 1 bed · 1 bath

This adorable casita has an incredible private patio, al fresco dining, outdoor seating, and water feature. The indoor and outdoor spaces flow seamlessly together, giving you that iconic San Diego living. The home has a kitchenette and on-site parking, and you’ll be centrally located to some of the city’s best restaurants, craft breweries, and famous sites.

20 guests · 10 bedrooms · 10 beds · 7 baths

This villa is in La Jolla on a cliff overlooking the ocean. You’ll have a swimming pool, hot tub, spacious outdoor lounge areas, al fresco dining, skylights and floor-to-ceiling windows, a pool table, and some of the most spectacular views in the city.

Spanish Hacienda

8 guests · 4 bedrooms · 7 beds · 2 baths

This 1930s historic home is a true urban oasis. The house has beamed and vaulted ceilings, a large chef’s kitchen, and a central courtyard with a pond and al fresco dining. You’ll never want to leave the desert-style outdoor living areas!

Tuscany-Inspired Villa

14 guests · 6 bedrooms · 9 beds · 4.5 baths

You’ll never want to leave this villa and its spectacular views. The home has a game room, library, gazebo, multiple outdoor patios and dining areas, an eight-person hot tub, and a saltwater pool, complete with a cave and waterfall. You’ll be about 20 minutes from downtown San Diego and close to the towns of Rancho Santa Fe and Escondido.

Urban Oasis

2 guests · 1 bedroom · 1 bed · 1 bath

This “urban treehouse” is an industrial penthouse with 180-degree city and bay views. The furnishings are vibrant and cozy, you’ll love the succulent-filled private patio, and the feature wall of multi-colored spirits and liquors is Insta-perfect.

Bayfront Living

9 guests · 3 bedrooms · 5 beds · 3 baths

You’ll love this modern bayside condo with stunning views of Mission Bay. Each bedroom has its own patio and bathroom, and floor-to-ceiling glass doors open to blend the indoor and outdoor living spaces. The luxurious patio has al fresco dining, a grill, and loungers. This home also comes with beach towels, beach chairs, a kayak, boogie boards, and two parking spaces.

Canyon Retreat

8 guests · 3 bedrooms · 4 beds · 2 baths

Nestled in a quiet, canyon culdesac, this home feels like it’s in the countryside, but you’re downtown, close to everything San Diego has to offer. The house has luxurious finishes, stylish furniture, cozy decor, a gourmet kitchen, and incredible outdoor dining and living spaces with beautiful canyon views.

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This article about San Diego luxury vacation home rentals is not a sponsored post, and the thoughts and opinions expressed in this post are entirely my own. Some of the links in this post about San Diego luxury vacation home rentals are affiliate links, and, at no cost to you, I may earn a small commission.